At what age does a woman stop ovulating?

When a woman's ovaries do not ovulate, they will slowly decline and age. At this time, women will enter menopause and their skin will age more and more seriously. Most women are afraid of getting old, not only because their skin will become worse and worse after getting old, but also because their bodies will be more susceptible to various diseases after getting old. So at what age do women stop ovulating?

As we all know, under normal circumstances, women will ovulate every month, except for pregnant women. This is a very normal process. Of course, some women do not ovulate or ovulate abnormally due to various physical reasons. So, at what age does a woman not ovulate? Let's find out.

The age of menopause is usually between 45 and 55 years old. The timing of menopause in women varies greatly from person to person and is related to many factors. Women of normal childbearing age ovulate once a month, usually about two weeks before the next menstrual period. The main organs that control ovulation are the hypothalamus, pituitary gland, and ovarian axis. The reasons for female anovulation include pituitary anovulation, hypothalamic anovulation, central nervous system anovulation, brain lesions, immune or mental factors. As long as women with anovulation receive reasonable treatment, the chances of normal ovulation and pregnancy are very high. But you must first find out the cause of the disease and then develop a diagnosis and treatment plan based on your specific situation.

The incidence of anovulation in infertility can be as high as 25% to 30%, and it is a common endocrine disease. In addition to infertility, patients often present with menstrual disorders, such as oligomenorrhea, infrequent menstruation or amenorrhea, heavy hair, obesity, etc. Due to long-term anovulation, excessive endometrial hyperplasia, and the lack of cyclical progesterone counteracting effect, the risk of developing endometrial cancer or breast cancer is relatively increased.

Normal ovulation depends on the complete regulatory function of the hypothalamus-pituitary-ovarian axis and the normal secretory function of the ovaries. The causes of ovulation disorders are often attributed to three aspects: dysfunction of the hypothalamic-pituitary axis, abnormal feedback mechanism and local ovarian factors.

Reasons why women do not ovulate

(1) Turner syndrome and simple gonadal dysgenesis are chromosomal abnormalities that both present with primary amenorrhea as the main clinical manifestation, with elevated gonadotropin and decreased estrogen. Pregnancy can be achieved through in vitro fertilization and embryo transfer using eggs donated by others.

(2) Premature ovarian failure and ovarian antagonism syndrome: Hypergonadotropic amenorrhea caused by ovarian failure that occurs before the age of 40 is called premature ovarian failure, which accounts for about 20% to 28% of primary amenorrhea and 4% to 20% of secondary amenorrhea. Women with primary amenorrhea or secondary amenorrhea before the age of 30 have elevated levels of endogenous gonadotropin and normal follicles in their ovaries, but are low-responsive to high-dose exogenous gonadotropin stimulation. This is called ovarian insensitivity syndrome or ovarian antagonism syndrome. The causes of both diseases are still unclear, and both present with amenorrhea and anovulation.

(3) Polycystic ovary syndrome: often manifested as amenorrhea or infrequent menstruation, long-term anovulation, excessive androgen, and no cyclical fluctuation of estrogen. It is currently a major cause of anovulatory infertility.

(4) Unruptured luteinized syndrome: In a normal menstrual cycle or a drug-induced ovulation cycle, an ovarian follicle develops into a dominant follicle, but the follicle does not disappear or continues to grow 48 hours after the LH peak during ovulation, and persists for several days. The granulosa cells have become luteinized, but the follicle has not ruptured. The basal body temperature (BBT), cervical viscosity and endometrial changes of LUFS are similar to normal ovulation, giving the illusion of ovulation. It is one of the causes of infertility and one of the reasons why the pregnancy rate of clomiphene-induced ovulation is low. Literature reports that the incidence of LUFS is between 31.8% and 2.9%, which is significantly higher than the 10% in the natural cycle. B-ultrasound monitoring shows that the follicles do not rupture or increase in size, and light spots appear in the follicles, which usually disappear before the next menstruation. If laparoscopy is performed, the ovulation orifice cannot be seen.