What should I do if my period doesn’t come at 35?

Menstruation is a unique reaction of the female body and the reason why the word "month" is included is because menstruation comes every month, unless you are pregnant or reach menopause in old age. However, there are some exceptions. For example, some women in their thirties suddenly find that their menstruation has not come one day. They have waited for a month but it still hasn't come, and they are not pregnant. What should they do?

1. Treatment of the cause

Some patients can resume menstruation after the cause is removed. For patients with neurological or mental stress causes, effective psychological counseling should be provided; those with amenorrhea caused by low body weight or excessive dieting or weight loss should adjust their diet and strengthen their nutrition; those with exercise-induced amenorrhea should appropriately reduce the amount of exercise and training intensity; for amenorrhea caused by the hypothalamus (cranial pharyngeal tumors), pituitary tumors (excluding tumors that secrete PRL) and ovarian tumors, the tumors should be surgically removed; for high-Gn amenorrhea containing Y chromosomes, the gonads have malignant potential and gonadectomy should be performed as soon as possible; amenorrhea caused by reproductive tract malformations and menstrual drainage disorders should be corrected surgically to ensure smooth menstrual blood flow.

2. Estrogen and/or progesterone therapy

Estrogen therapy should be used to treat amenorrhea caused by adolescent sexual immaturity and adult hypoestrogenism. The principles of medication are as follows:

(1) Promote bone growth

For adolescent patients with sexual immaturity, when their height has not yet reached the expected height, treatment should be started with a small dose, such as 17β-estradiol or estradiol valerate, or conjugated estrogens; the dose can be increased after the height reaches the expected height.

(2) Promote further development of sexual characteristics

Adults with amenorrhea due to hypoestrogenemia should first use 17β-estradiol or estradiol valerate, or combined estrogens, to promote and maintain overall health and sexual development. After the uterus develops, progestins should be added regularly according to the degree of endometrial proliferation, or estrogen and progestin sequential cyclic therapy should be used. It is recommended that natural or near-natural progestins, such as dydrogesterone and micronized progesterone, be used for cyclical therapy in adolescent women, which are beneficial to the recovery of reproductive axis function. For patients with signs of androgen excess, progestin formula preparations containing anti-androgen effects can be used. For amenorrhea patients with a certain level of endogenous estrogen, progestin treatment should be used regularly to allow the endometrium to shed regularly.

3. Endocrine therapy for disease pathology and physiological disorders

According to the etiology, pathological and physiological mechanisms of amenorrhea, targeted endocrine drug treatment is used to correct the disordered hormone levels in the body and thus achieve the treatment goal. For example, CAH patients should be treated with long-term glucocorticoids; PCOS patients with obvious signs of hyperandrogenism can be treated with combined estrogen and progesterone oral contraceptives; PCOS patients with combined insulin resistance can be treated with insulin sensitizers. The above treatment can restore menstruation in patients, and some patients can resume ovulation.

4. Induce ovulation

For patients with low Gn amenorrhea, after estrogen therapy is used to promote the development of reproductive organs and the endometrium has responded to estrogen and progesterone, human gonadotropin (hMG) combined with human chorionic gonadotropin (hCG) can be used to promote follicle development and induce ovulation. Since it may cause ovarian hyperstimulation syndrome (OHSS), the use of Gn to induce ovulation must be performed by an experienced physician under the conditions of B-ultrasound and hormone level monitoring; for amenorrhea patients with normal FSH and PRL levels, clomiphene citrate can be the first choice as an ovulation-inducing drug because the patient has a certain level of endogenous estrogen in the body; for amenorrhea patients with elevated FSH levels, ovulation-inducing drugs are not recommended due to their ovarian failure.

5. Assisted Reproductive Treatment

Assisted reproductive technology can be used for patients who desire to have children, who have failed to become pregnant after induced ovulation, who have amenorrhea and combined with fallopian tube problems, or who are infertile due to male factors.