Is taking butaclostrobin effective during breastfeeding?

Women who are breastfeeding are prone to problems such as indigestion due to eating a lot of food every day. In severe cases, they may also develop stomach lesions. At this time, treatment and conditioning are needed. Metoclopramide is a commonly used stomach medicine. Everyone knows that breastfeeding women cannot take medicine casually, because the medicine will be passed to the child through breast milk and have an adverse effect on the child's development. Let’s take a look at whether taking butacloprid is effective during breastfeeding.

Women who are breastfeeding can take metoclopramide in small amounts. It is recommended that breastfeeding be interrupted during the medication period and resumed 12 hours after taking the medication.

Metoclopramide and domperidone tablets are commonly used medicines for indigestion, mainly used for indigestion caused by delayed gastric emptying, gastrointestinal reflux, esophagitis, etc.

Metoclopramide is a peripheral dopamine receptor antagonist that can promote the peristalsis and tension of the upper gastrointestinal tract to return to normal, promote gastric emptying, increase intestinal motility of the gastric antrum and duodenum, coordinate the contraction of the pylorus, and also enhance the peristalsis of the esophagus and the tension of the lower esophageal sphincter. Because it has poor penetration into the blood-brain barrier and has almost no antagonistic effect on dopamine receptors in the brain, it can eliminate psychiatric and central nervous system side effects.

It is rapidly absorbed after oral administration, and the blood concentration reaches its peak in 15 to 30 minutes. Except for the central nervous system, it is widely distributed in other parts of the body. Due to the "first-pass effect" liver metabolism and intestinal wall metabolism, oral bioavailability is low. The half-life of this product is 7 hours. After oral administration, about 30% is excreted in the urine within 24 hours and about 60% is excreted in the feces within 4 days.

This product can block the effect of dopamine in the emetic chemosensory area and inhibit the occurrence of vomiting; it can promote the peristalsis and tension of the upper gastrointestinal tract to return to normal, and can accelerate gastric emptying after meals. In addition, it can also increase the tension of the cardiac sphincter and promote the expansion of the pyloric sphincter after meals. However, this product does not affect the secretion of gastric juice. Because it has a weak ability to pass through the blood-brain barrier, it has no obvious sedation, drowsiness, or extrapyramidal side effects.

To sum up, there are many contraindications for using Western medicine. For example, it is forbidden for patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, gastrointestinal bleeding and other diseases, and it is only allowed for breastfeeding women to take it under certain conditions.