Trimethoprim-sulfamethoxazole cream is used for skin eczema, contact dermatitis, seborrheic dermatitis, neurodermatitis, tinea corporis, tinea cruris, tinea manuum and pedis, etc. Element This product is a compound preparation, and its ingredients are: every 10g contains 100mg of miconazole nitrate, 10mg of triamcinolone acetonide glacial acetate, and 30,000 enterprises of neomycin sulfate. characteristic This product is a milky white cream of solvent-based cultivation medium. Scope of application Used for skin eczema, contact dermatitis, seborrheic dermatitis, neurodermatitis, tinea corporis, tinea cruris, tinea manuum and pedis, etc. Usage method Dosage For external application. Apply to the skin injuries immediately, 2 to 3 times a day. side effect 1. Some medications may cause allergic symptoms. 2. Skin burning sensation, itching, pricking sensation, hematoma, etc. may occur. 3. Long-term use may lead to partial skin atrophy, capillary dilation, excessive hair growth and secondary infection. taboo Patients with skin allergies to the ingredients of this product are prohibited from using it. Frequently asked questions 1. To prevent recurrence, the treatment course for skin candidiasis and various tinea diseases should be at least 2 weeks, and for tinea pedis at least 1 month. 2. Avoid partial coverage with medical dressings when treating candidiasis. 3. Prevent long-term and large-scale application. Taking medication during pregnancy and breastfeeding Not yet established. Pediatric medication Children should be cautious when using it for a long time. Drug interactions If you are already using other topical medications, please consult your doctor or physician before using this product. Pharmacology and Toxicology 1. Pharmacology Miconazole nitrate is a broad-spectrum antifungal drug. At a concentration of 4 mg/L, it can inhibit the growth of most bacteria. This product inhibits the production of ergosterol, a key steroid in the bacterial cytoplasm, by affecting the specificity of cytochrome P450, damaging the bacterial cytoplasm and changing its permeability, resulting in the exposure of key intracellular substances; this product can also inhibit the production of triglycerides and unsaturated fatty acids in bacteria, inhibit the activity of antibiotics and peroxidases, and cause the accumulation of hydrogen peroxide in cells, resulting in cell submembrane optical transformation and cell necrosis. For Candida albicans, it can inhibit the entire process of its transformation from spores to invasive fungi. Triamcinolone acetonide acetate has the anti-infection, anti-allergy and vasoconstriction effects of topical corticosteroids. Neomycin sulfate has excellent efficacy against Staphylococcus (methicillin-sensitive strains) and Corynebacterium, and also has excellent efficacy against Enterobacteriaceae such as Escherichia coli, Klebsiella, and Proteus. It has poor specificity for each group of streptococci, pneumococci, and enterococci. Pseudomonas aeruginosa and Pseudomonas aeruginosa are resistant to this product. The bacteria have partial or complete cross-resistance to streptomycin, neomycin, kanamycin and penicillin. toxicology It has no irritating effect on the skin and mucous membranes of rabbits and mice. |
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