Diabetes and obesity

The relationship between diabetes and obesity

Many diabetic patients are obese, and the blood sugar-lowering effect and prognosis for this group of people are relatively poor.

Today we are going to talk about the relationship between diabetes and obesity

Overweight and obesity are independent risk factors for type 2 diabetes. Among obese people, the incidence of type 2 diabetes increases year by year. More than 90% of diabetes patients in my country suffer from type 2 diabetes, and the incidence rate increases year by year. Patients with type 2 diabetes are often accompanied by systemic or abdominal obesity. Obesity leads to insulin resistance, which hinders pancreatic function and forms a vicious circle. Moreover, due to obesity, patients are insensitive to insulin, which leads to increased dosage of hypoglycemic drugs and even failure of sulfonylurea treatment.

Obesity is not only a chronic disease that endangers health, but also an important risk factor for a variety of chronic non-communicable diseases such as type 2 diabetes, cardiovascular and cerebrovascular diseases, and respiratory diseases. It is a global public health issue that affects the quality of life of patients.

Due to excessive energy intake, the adipose tissue of obese people reaches the maximum storage capacity, and the excess energy is released into the blood in the form of fatty acids and transported to other organs, resulting in an increase in free fatty acids (FFA) in the blood. When FFA transport to the liver increases, triglyceride accumulation in the liver increases, resulting in increased glucose output from the liver, reduced insulin uptake and insulin resistance. Increased levels of FFA and triglycerides in the circulation cause triglycerides to deposit in the muscles, impairing insulin signal transduction and metabolic enzyme activity.

High concentrations of FFA cause lipids to deposit in the pancreas, leading to reduced glucose-induced insulin release, impaired proinsulin synthesis, and increased B cell apoptosis. Eventually, various tissues and organs produce IR, which runs through the entire course of obesity-type 2 diabetes. Obesity-type 2 diabetes and IR are closely linked and inseparable. Under certain conditions, the two are mutually causal and mutually infiltrated, eventually forming a vicious cycle.

Therefore, diabetic patients with obesity must pay more attention. In addition to blood sugar-lowering treatment, weight loss treatment is also essential!

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Expert introduction

Zhang Jibin

Deputy Director of Traditional Chinese Medicine Surgery, the Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

Medical Director of Liaoning Lida Diabetes Hospital of Traditional Chinese Medicine

Podiatrist attending physician

Head of Key Disciplines of Liaoning Provincial Administration of Traditional Chinese Medicine

Young member of the Ulcer Committee of the Chinese Association of Integrated Traditional Chinese and Western Medicine

Member of the Expert Committee of the Pressure Group of the Peripheral Vascular Disease Professional Committee of the Chinese Microcirculation Society

Member of the Science Popularization and Health Education Center of China Medical Education Association

He has been engaged in the treatment of diabetic foot for 17 years. He is good at the diagnosis and treatment of chronic complications of diabetes and diabetic foot caused by various causes. He has rich clinical experience in the diagnosis and treatment of endocrine-related diseases such as thyroid and gout.