Taking "Lijing" type hypoglycemic drugs, do you feel that your urine is sticky on your feet? This shows that the drug is effective in lowering blood sugar and protecting cardiovascular health.

A diabetic patient told Huazi that after taking empagliflozin, his blood sugar level dropped, but he could smell a sweet smell when urinating, and sometimes he accidentally leaked urine on the ground, which would stick to his feet. Huazi told him not to worry, because "empagliflozin" drugs produce a blood sugar-lowering effect by increasing urinary sugar excretion, and in addition to lowering blood sugar, they can also reduce weight, lower blood pressure and protect the cardiovascular system. However, he may be drinking too little water and needs to increase his water intake.

1. The glucose-lowering mechanism of "Lipfloxacin" type glucose-lowering drugs "Lipfloxacin" type glucose-lowering drugs are a new type of glucose-lowering drugs. Currently, there are dapagliflozin, empagliflozin and canagliflozin. This type of drug is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, which produces pharmacological effects by inhibiting SGLT-2.

We learned in junior high school physiology class that the original urine filtered by the glomerulus contains glucose, but the final urine does not contain glucose. This is because the human renal tubules have a reabsorption function and will reabsorb 100% of the glucose in the original urine back into the blood. The reabsorption function of the renal tubules for glucose is achieved through the sodium-glucose co-transporter (SGLT), including SGLT-1 (accounting for about 10% of the reabsorption) and SGLT-2 (accounting for about 90% of the reabsorption).

In other words, SGLT-2 is a hard-working "porter" that actively transports glucose in the original urine back to the blood. Moreover, the upregulation of SGLT-2 expression in diabetic patients means that the "porter" will be more diligent and reabsorb more glucose. The role of "lejing" drugs is to inhibit the activity of the "porter", reduce the reabsorption of glucose by the renal tubules, increase urine sugar, and allow the excess glucose in the body to be excreted through urine.

So after taking the "Lijing" type of hypoglycemic drugs, there will be glucose in the urine, which is the normal effect of the drug. If you smell a sweet smell when urinating, or have a "sticky feet" phenomenon, it may mean that you drink too little water and the concentration of glucose in the urine is too high. You should drink more water to dilute the urine.

2. Multiple effects of “Liejing” type hypoglycemic drugs 1. Hypoglycemic: By inhibiting SGLT-2, glucose is excreted from the urine, producing a hypoglycemic effect.

2. Weight loss: On average, glucose-lowering drugs such as Liposuction will cause about 80 grams of glucose to be excreted in the urine every day, which can be converted into about 300 calories, equivalent to eating one less bowl of rice, or the calories consumed by walking normally for one hour. When the drug is used continuously, weight will be reduced.

When used in combination with insulin or insulin secretion-promoting drugs, "Lejing" type hypoglycemic drugs can reduce the dosage of the latter and reduce the weight gain caused by insulin.

3. Blood pressure reduction: "Lejing" drugs inhibit sodium-glucose co-transporter 2. While inhibiting glucose reabsorption, they also inhibit sodium ion reabsorption, increasing the excretion of sodium ions in urine. It will produce an effect similar to that of diuretic antihypertensive drugs, reducing the body's blood volume, reducing sodium ions in the body, and promoting lowering of blood pressure.

4. Protect cardiovascular system: By controlling blood sugar and promoting sodium ion excretion, glucose-lowering drugs of the "Liejing" class can delay the progression of atherosclerosis, improve myocardial ischemia, reduce cardiac load, and protect cardiovascular system. Clinical trials have shown that glucose-lowering drugs of the "Liejing" class can significantly reduce the risk of adverse cardiovascular events and the rate of hospitalization for heart failure.

5. Protect the kidneys: The expression of SGLT-2 in diabetic patients increases, and the renal tubular reabsorption of sodium ions and glucose increases, resulting in a hyperfiltration state, which is considered to be one of the early factors causing kidney damage. "Liejing" type hypoglycemic drugs can inhibit SGLT-2, alleviate the hyperfiltration state of the kidneys of diabetic patients, help protect the kidneys, and delay the progression of diabetic nephropathy.

6. Lowering uric acid: Clinical studies have found that "Liejing" type hypoglycemic drugs can also increase the excretion of uric acid and reduce blood uric acid levels.

7. Impact on blood lipids: “Levitra” type hypoglycemic drugs inhibit cholesterol metabolism, causing a slight increase in low-density lipoprotein cholesterol (LDL-C) which is harmful to cardiovascular system and high-density lipoprotein cholesterol (HDL-C) which is beneficial to cardiovascular system. However, the slight increase in LDL-C and HDL-C does not affect the protective effect of “Levitra” type hypoglycemic drugs on cardiovascular system.

3. Precautions for hypoglycemic drugs of the "Liejing" type Hypoglycemic drugs of the "Liejing" type will cause sugar in the urine, which will increase the risk of urinary tract and reproductive tract infections. Especially for women with shorter urethras, the chance of infection is about 3 to 4 times that of men. Therefore, during the period of taking the drug, you should increase the amount of water you drink to ensure sufficient urine volume, which can have a "cleansing" effect on the urinary tract and prevent urinary tract infections. If an infection occurs, symptomatic treatment should be given in a timely manner.

There is no need to adjust the dosage of "Lijing" drugs when used by patients with impaired liver function. However, patients with impaired renal function should be aware that if the glomerular filtration rate is less than 60, dapagliflozin is not recommended; if the glomerular filtration rate is less than 45, canagliflozin and empagliflozin are not recommended. For people with low blood pressure or insufficient blood volume, it is not recommended to use "Lijing" drugs before the low blood pressure and low blood volume are corrected.

To sum up, "Liejing" type hypoglycemic drugs excrete glucose through urine. In addition to lowering blood sugar, it also has the effects of lowering blood pressure, lowering uric acid, and protecting the kidneys and cardiovascular system. During medication, you should pay attention to increasing your water intake and urinating more to prevent urinary tract infections. "Liejing" type drugs are prescription drugs and must be used under the guidance of a doctor. If you find any problems during medication, please consult a doctor or pharmacist in time. I am pharmacist Huazi, welcome to follow me and let me be the pharmacist by your side.