Why are your blood pressure medications becoming less effective? Check out these 6 reasons. Which one do you fall for?

For patients with primary hypertension, taking antihypertensive drugs regularly for a long time is the most reliable way to control blood pressure. However, during the treatment process, many patients with hypertension have questions: Will they develop drug resistance if they take the same antihypertensive drug for a long time? Why is the antihypertensive effect not as good as before when taking the same drug and the same dosage?

Huazi replied that first of all, it is certain that antihypertensive drugs do not have obvious drug resistance. If you take the same antihypertensive drugs for a long time and your blood pressure control becomes worse and worse, it is most likely caused by other reasons.

1. Drug resistance to antihypertensive drugs can be ignored Most people know about drug resistance from sedatives, hypnotics, antibiotics and other drugs. Specifically, as the duration of continuous medication increases, the drug effect decreases or even becomes ineffective. Sedatives and hypnotics develop resistance because the central nervous system is less sensitive to drug stimulation; antibiotics develop resistance because pathogens mutate.

Commonly used antihypertensive drugs do not act on the central nervous system, but directly act on peripheral tissues and organs such as the heart, blood vessels, and kidneys. The tissues and organs of the human body do not mutate, so from the perspective of the drug mechanism, antihypertensive drugs will not produce obvious drug resistance. Even if there is drug resistance, it is very weak and can be ignored in long-term antihypertensive treatment.

2. 6 reasons why antihypertensive drugs fail 1. Unhealthy lifestyle: Unhealthy lifestyle is a common reason for antihypertensive drugs to fail. Many people think that everything will be fine after taking antihypertensive drugs, so they indulge themselves, eat a high-salt, high-fat, high-sugar diet, and do not exercise enough. These unhealthy lifestyles will antagonize the effect of antihypertensive drugs.

For patients with hypertension, lifestyle intervention is as important as drug treatment. For patients with mild hypertension, blood pressure can be controlled without medication by improving a healthy lifestyle. A bad lifestyle will only make your blood pressure worse.

2. Tension and anxiety: For women and younger patients with hypertension, the reason why antihypertensive drugs fail is often due to long-term tension and anxiety. Especially for people with sensitive personalities, when they encounter pressure from work, family, etc., they will fall into tension and anxiety, which increases the tension of sympathetic nerves and causes high blood pressure.

3. Sleep disorders: Lack of sleep can cause high blood pressure. Sleep disorders include difficulty falling asleep, early awakening, dreaming, shallow sleep, etc. Some people suffer from sleep apnea syndrome, especially obese people. When they are tired or drinking, they will snore loudly. They seem to sleep soundly, but in fact their breathing is restricted, causing hypoxia in the body, which eventually leads to high blood pressure and poor drug effect.

4. Seasonal changes: Human blood pressure is lower in summer and higher in winter. Especially in northern my country, the temperature difference between winter and summer is large, and the phenomenon of blood pressure fluctuation with the season is more obvious. This type of hypertensive patients need to adjust their antihypertensive drugs as the seasons change.

5. Disease progression: Hypertension is a disease that will continue to progress with age, so as age increases, blood pressure will also increase year by year. Some hypertensive patients have poor blood pressure control, or have other chronic diseases such as diabetes and hyperlipidemia, which cause renal artery stenosis and secondary hypertension.

6. Drug reasons: Improper storage of antihypertensive drugs, heat or moisture will make the drugs ineffective. Some elderly people like to buy a large amount of drugs at one time, which results in ineffectiveness due to long storage time. There are also drugs of the same specifications, but different manufacturers, and different processes and excipients used, which may also lead to differences in efficacy and cause high blood pressure.

3. Communicate more with your doctor during medication Most patients with hypertension feel that the effect of medication is getting worse while taking medication. This is probably due to one or more of the above reasons. You can analyze the reasons yourself and make corrections. If you can't find the reasons, you should seek help from your doctor in time.

Don’t think that antihypertensive drugs are ineffective and increase the dosage or change to other drugs on your own. Each antihypertensive drug has its own indications and contraindications. Drug adjustments need to be made under the guidance of a doctor.

In summary, antihypertensive drugs do not produce obvious drug resistance. If you find that the effect of the drug is getting worse during the antihypertensive process, it is likely caused by other reasons. Pay more attention to your blood pressure and communicate with your doctor more often if you have any problems to ensure the effectiveness of antihypertensive treatment. I am pharmacist Huazi, welcome to follow me and share more health knowledge.