How to avoid luteinization of ovarian follicles

Luteinization of follicles mainly means that the follicles have matured but have not ruptured. When this happens, it will lead to infertility in women, so we must pay attention to treatment and prevention and understand the specific causes. In order to avoid luteinization of follicles, the ovulation system should be monitored. Let’s take a brief look at how to avoid luteinization of follicles.

How to avoid luteinization of ovarian follicles

1. Luteinization of follicles is mostly found in the systematic monitoring of follicular development and ovulation in infertile patients, and LUF does not occur in every menstrual cycle. Therefore, its prevention and treatment is only of clinical significance for infertility. Since LUF does not occur in every cycle, the authors believe that it is more appropriate to treat after LUF occurs in two consecutive menstrual cycles.

2. There is no mature experience in the prevention and treatment of LUF, and the therapeutic effect is less than ideal. Most people advocate using HCG (10,000-15,000 IU) to stimulate ovulation when the follicles reach maturity as monitored by ultrasound. It has been reported that luteinized follicles are divided into two types, mature and precocious. When the follicle reaches the size of a mature follicle (average diameter 18-24mm), and estradiol > 734pmol/L and progesterone < 7.95nmol/L, it is considered to be in the maturation stage. When the follicles have not reached the size of mature follicles and progesterone is >7.95nmol/L, it is precocious. For the mature type, it is recommended to use HCG or: HCG and HMG injection at the same time to stimulate ovulation and achieve certain results. For precocious puberty, larger amounts of estrogen or GnRH-A can be used to inhibit follicle development, and then HMG can be used to induce follicle growth. For those with small (not reaching the size of mature follicles) and luteinized follicles, it is recommended to use chlorsucralose or HMG to promote follicle development, and then use HCG to stimulate ovulation when the follicles are mature.

3. The prevention and treatment of luteinized follicles is only for infertile people, because luteinized follicles is not a persistent disease. When taking the medicine, it cannot be predicted that LUF will occur in this cycle. It can be seen that the purpose of taking the medicine is to prevent LuF from occurring again in this cycle and affecting conception. In fact, if ovulation occurs after taking the medicine, it may be the effect of treatment or it may be natural ovulation, so the efficacy of LUF is more difficult to judge accurately.