What to do if non-invasive DNA is high risk

What to do if non-invasive DNA is high risk

Many people may not be so clear about the high-risk situation of non-invasive DNA. In fact, every pregnant woman should do this prenatal test during pregnancy. Only in this way can it be clearly determined whether her baby carries some viruses in the body or suffers from some chromosomal abnormalities. If it is confirmed, try not to continue the pregnancy and must terminate it in time.

Non-invasive DNA prenatal testing is also known as non-invasive prenatal DNA testing, non-invasive fetal chromosome aneuploidy testing, etc. According to the American College of Obstetricians and Gynecologists Committee, an internationally recognized academic organization, non-invasive prenatal DNA testing (Non-invasive Prenatal Testing) is the name of the most widely used technology.

Non-invasive DNA prenatal testing technology only requires the collection of venous blood from pregnant women, and uses the new generation of DNA sequencing technology to sequence the free DNA fragments (including fetal free DNA) in the maternal peripheral plasma. The sequencing results are then subjected to bioinformatics analysis, from which the genetic information of the fetus can be obtained, thereby detecting whether the fetus suffers from the three major chromosomal diseases.

When pregnant women in the following situations are tested, the accuracy of the test will decrease to a certain extent and the detection effect is still unclear; or they should be recommended to undergo prenatal diagnosis according to relevant regulations. include:

1. Prenatal screening in early and mid-pregnancy is high risk.

2. The expected age at delivery is ≥ 35 years old.

3. Severe obesity (body mass index > 40).

4. Conception through in vitro fertilization and embryo transfer.

5. There is a history of giving birth to a fetus with chromosomal abnormalities, excluding cases where the couple has chromosomal abnormalities.

6. Twin and multiple pregnancy.

6. Other circumstances that the physician believes may affect the accuracy of the results. [4]

If a pregnant woman has the following conditions, the test may seriously affect the accuracy of the results. include:

1. Gestational age < 12 weeks.

2. One of the spouses has a clear chromosomal abnormality.

3. Received allogeneic blood transfusion, transplantation surgery, allogeneic cell therapy, etc. within 1 year.

4. If fetal ultrasound examination indicates structural abnormalities, prenatal diagnosis is required.

5. A family history of genetic disease may indicate that the fetus is at high risk of developing a genetic disease.

6. Malignant tumors during pregnancy.

7. Other circumstances that the physician believes may significantly affect the accuracy of the results.

Except for the above-mentioned inapplicable situations, pregnant women or their families may choose prenatal testing of fetal free DNA in the pregnant woman's peripheral blood with full informed consent. [4]

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