What are the symptoms of rheumatism in women

Rheumatism is a problem that many older people are prone to. Especially when they were young, they had symptoms of pain, but they did not pay attention to it. When they got older, their joints began to "forecast the weather". When your joints hurt, you know the weather is going to change. You will also feel like you can’t hold on if you stand for a long time. The probability of women suffering from rheumatism is not low, because many girls nowadays do not pay attention to keeping warm when they are young. So what are the symptoms of rheumatism in women?

Most women with rheumatic diseases suffer from symmetrical swelling and pain in the joints. You can go to the rheumatology and immunology department for a consultation, have your blood drawn for three rheumatic tests and other symptomatic tests, and after a clear diagnosis, give active symptomatic treatment. Early detection and early treatment are important. You can also do a gastroscopy to rule out stomach problems.

Rheumatism is a group of diseases that mainly affect joints, bones, muscles, blood vessels and related soft tissues or connective tissues, most of which are autoimmune diseases. The onset is often hidden and slow, the course of the disease is long, and most cases have a genetic predisposition. Both diagnosis and treatment are somewhat difficult; different autoantibodies can be detected in the blood, which may be related to different HLA subtypes; there is a good short-term or long-term relief response to non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and immunosuppressants.

Causes

1. Immune response : The body's stimulation of exogenous or endogenous antigens directly or through macrophage presentation activates the corresponding T cells, and some T cells produce a large number of various inflammatory cytokines, causing varying degrees of damage or destruction to various tissues and organs; some T cells then activate B cells to produce a large number of antibodies, which directly or combine with antigens to form immune complexes, causing damage or destruction to tissues or organs. In addition, monocyte chemoattractant proteins (such as MCP-1) produced by monocytes, etc.

2. Genetic background : Recent studies have shown that some rheumatic diseases, especially connective tissue diseases, are closely related to genetics and patient susceptibility and disease expression, which has certain significance for early or atypical cases and prognosis of the disease; among them, HLA (human tissue leukocyte antigen) is the most important.

3. Infectious factors : According to research over the years, a variety of infectious factors, antigens or superantigens produced by microorganisms can directly or indirectly stimulate or initiate immune responses.

4. Endocrine factors : Studies have shown that the imbalance of estrogen and progesterone is related to the occurrence of various rheumatic diseases.

5. Environmental and physical factors : ultraviolet rays can induce SLE.

6. Others : Some drugs such as procainamide and some oral contraceptives can induce SLE and ANCA-positive vasculitis.