Elevated human epitesticular protein 4 in women

Human epididymal cyst protein 4 is a tumor marker. It is mainly of practical significance in conjunction with CA125 for the diagnosis of female ovarian epithelial cell tumors. However, its specificity is not very high. It does not mean that if the human epididymal cyst protein 4 is high, ovarian epithelial cell tumors will definitely occur. Next, let's discuss why female epididymal cyst protein 4 is higher?

What is the reason for high levels of protein 4 in human epididymal cysts?

Human epididymal cyst protein 4 is a tumor marker. It is mainly of practical significance in conjunction with CA125 for the diagnosis of female ovarian epithelial cell tumors. However, its specificity is not very high. It does not mean that if the human epididymal cyst protein 4 is high, ovarian epithelial cell tumors will definitely occur. Because women's severe pelvic inflammatory disease can also cause higher levels of epididymal protein IV. Therefore, if this value is high, it is recommended to combine ultrasound or MRI to see whether there are certain space-occupying lesions in the uterus and ovaries. If there is a space-occupying disease in the uterus or ovary, you can consider a puncture biopsy or surgical treatment.

Clinical manifestations of human epididymal cyst protein 4:

Human epididymal cyst protein 4, also known as HE4, is a new tumor marker. Generally, some tumor screening is done as a service-based basis for diagnosis. An increase in the level of human epididymal cyst protein is generally associated with gynecological malignant tumors, such as uterine and ovarian cancer. Especially in the early stages of ovarian cancer, when it is difficult to diagnose, testing this indicator value can help to confirm the diagnosis if an abnormal increase is found, combined with relevant clinical manifestations.

Normal range of human epididymal cyst protein 4:

The normal reference range of human epididymal cyst protein 4 is 0 to 91080 mol/L. Human epididymal cyst protein 4 is a sensitive indicator for detecting ovarian cancer and is one of the tumor markers. Compared with carbohydrate antigen CA125, it is less affected by external factors. CA125 is generally affected by inflammation, endometriosis, pregnancy and many other factors, which will cause an increase, while human epididymal cystic protein 4 is generally not affected by these factors. The combined detection of human epididymal cystic protein 4 and CA125 is more meaningful for the detection of ovarian cancer.