Does insulin resistance affect pregnancy? Experts are here to answer!

Anyone who has studied biology in high school knows about insulin, but many people don’t know what insulin resistance is. In fact, the so-called insulin resistance refers to the simultaneous occurrence of high blood lipids, high blood pressure, high uric acid, high body weight, etc. in the human body. The human metabolism will become disordered, prone to blood sugar, dyslipidemia, etc. Most patients will be fatter. Obviously, so many diseases appearing in the body at the same time are too harmful to health, and it is easy to develop multiple diseases, especially causing other complications, so timely treatment is needed. Women need to be reminded that insulin resistance will directly affect pregnancy.

First, does insulin resistance affect pregnancy?

OK.

1. Insulin resistance causes unstable blood sugar, but controlling blood sugar within the normal range through oral medication or the use of insulin will not affect pregnancy.

2. Insulin resistance not only accelerates the occurrence and development of type 2 diabetes, but also increases the risk of cardiovascular diseases. Therefore, insulin resistance must be detected and treated early.

3. Insulin resistance has nothing to do with pregnancy. It is recommended to go to the hospital to check blood sugar to see if it is normal.

Second, how to prevent insulin resistance

1. Exercise and diet combination

Obese people emphasize a reasonable diet plan to reduce weight. At the same time, engage in long-term, scientific and regular exercise to reduce weight.

2. Ideal blood sugar control

Insulin resistance leads to hyperglycemia, and long-term hyperglycemia further aggravates the insulin resistance of tissues such as muscle, fat and liver through its "glycotoxicity". Therefore, in clinical work, reasonable hypoglycemic treatment for hyperglycemia in patients with type 2 diabetes can help reduce insulin resistance by achieving sustained good control of blood sugar. In recent years, many clinical research reports have shown that for some newly diagnosed type 2 diabetic patients with significantly elevated blood sugar or secondary failure of oral anti-diabetic drugs, intensive insulin therapy can stabilize blood sugar control and significantly improve insulin resistance in the short term, which will help them control blood sugar in the future.

3. Antidiabetic drugs

For patients with type 2 diabetes who are mildly to moderately obese or overweight, insulin resistance is the main symptom. Antihypertensive drugs such as thiazolidinedione derivatives or insulin sensitizers - rosiglitazone or pioglitazone; biguanides or glucocorticoid inhibitors - glucagon should be the first choice. In addition, for patients with type 2 spermatopathy who are treated with sulfonylureas or insulin and whose blood sugar control is not ideal, the above-mentioned anti-hyperglycemic drugs can be used in combination according to the specific situation to achieve a synergistic blood sugar-lowering effect.

Individualized selection of hypotensive resistance has adverse effects on glucose metabolism and long-term high-dose application should be avoided. Calcium ion blockers have no adverse effects on glucose metabolism; α-receptor blockers, angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers can slightly improve insulin resistance while lowering blood pressure, which may reduce the risk of diabetes in hypertensive patients to a certain extent.

How to treat insulin resistance

Currently, insulin sensitizers are the first choice for treating insulin resistance. Insulin sensitizers are mainly thiazolidinediones, such as rosiglitazone, pioglitazone, etc., which are particularly effective in diabetic patients with acquired obesity.

If the main problem is insulin resistance, and it is in the early stages and the course of the disease is relatively short, simply taking sensitizers can have a good effect. Studies have reported that once the right people are adapted to the drug, the effects are very stable and can be taken continuously.

If the course of the disease is long, not only is there insulin resistance, but the function of endogenous pancreatic islets is also relatively poor, then combination medication is needed, which can be combined with insulin secretagogues. If insulin resistance is severe and the person is obese, biguanides can be used in combination. It can also be used in combination with glycosidase inhibitors, exogenous insulin, etc.

In addition to improving blood sugar control, insulin sensitizers can also lower blood triglyceride levels, increase high-density lipoprotein cholesterol, and have a certain therapeutic effect on fatty liver; they can lower blood pressure, slow the rate of arteriosclerosis, improve blood vessel wall elasticity, etc., thereby significantly reducing the risk of myocardial infarction in diabetic patients.

Insulin sensitizers also have side effects. For example, some patients may have liver intolerance, so liver function needs to be tested regularly. It is recommended to check liver function every two months or so. However, rosiglitazone (such as rosiglitazone hydrochloride, trade name Vigolo) has not been found to cause serious liver problems so far. It is relatively safe and has few side effects. Mild edema may also occur, which is not good for patients with heart failure. Therefore, people with abnormal liver function, severe heart failure, pregnant women or women who may become pregnant, type 1 diabetes, and diabetes ketoacidosis are not suitable for using insulin sensitizers. Other symptomatic patients can take it long-term.