What are the symptoms of uterine leiomyosarcoma?

Uterine leiomyosarcoma is a common tumor in female genitals. If not treated in time, it will have a great impact on genital health. To discover a disease, you must first understand some of the symptoms of the disease so that you can distinguish it in time.

1. Symptoms

Generally there are no special symptoms, but it may manifest as symptoms similar to uterine fibroids.

1. Irregular vaginal bleeding:

The most common symptoms. Bleeding may last for several days and may be accompanied by sudden heavy vaginal bleeding.

2. Compression symptoms:

Larger tumors compress the bladder or rectum, causing frequent urination, urgency, urinary retention, constipation, etc.

Compression of the pelvic cavity: affecting the venous and lymphatic return of the lower limbs, causing lower limb edema, etc.

3. Lower abdominal pain, falling and other discomfort:

Sarcomas develop rapidly, the tumor expands excessively or there is bleeding and necrosis within the tumor, or the sarcoma invades and penetrates the uterine wall, causing rupture and bleeding of the serosal layer and acute abdominal pain.

4. Abdominal mass:

If a lump is felt in the lower abdomen, the possibility of uterine sarcoma should be considered.

If fibroids do not shrink after menopause or even grow larger, they should be considered as malignant.

5. Other symptoms:

In the late stage, symptoms such as weight loss, general fatigue, anemia, and low fever may appear.

Metastasis to the brain: symptoms such as headache and paralysis of the lower limbs appear.

Metastasis to the lungs: cough and hemoptysis occur.

2. Diagnosis

1. Physical signs diagnosis

(1) Pelvic and abdominal masses, or ascites, abdominal pain, and back pain.

(2) Gynecological examination shows that the lump may be hard or soft, and the surface may be uneven or nodular.

2. Diagnostic indicators: based on the density of tumor cell proliferation, the degree of cell atypia and the number of nuclear division figures.

(1) The tumor cells are abundant, with a high degree of cellular atypia and more than 5 mitotic figures per 10 HPFs.

(2) Moderate to severe atypia with more than 2 mitotic figures/10 HPF.

(3) Tumor cells invade the muscular layer or blood vessels and have pathological nuclear division.

(4) The number of mitotic figures in the most active area of ​​the tumor is counted, with 10/HPFs being used as the standard for distinguishing benign from malignant tumors.