What are the causes of rheumatism in women?

People are prone to rheumatism when they reach middle age, especially in the hot, humid and rainy south where many people suffer from it. Many women get sick not because of the weather, but because they are often exposed to cold water, cold drinks and wind during the confinement period after giving birth, which leads to rheumatism. Even in summer, they will feel cold, weak and tired. Young women often do not pay attention to postpartum care. It is not advisable to let momentary pleasure lead to serious consequences. If a depressed and anxious mother is not good at regulating her emotions, it can easily cause obstruction of qi and blood. In addition, if she does not pay attention to keeping warm, it is also one of the causes of rheumatism in women.

1. Immune response: The body's stimulation of exogenous or endogenous antigens directly or through macrophage presentation activates the corresponding T cells, and some T cells produce a large number of various inflammatory cytokines, causing varying degrees of damage or destruction to various tissues and organs; some T cells then activate B cells to produce a large number of antibodies, which directly or combine with antigens to form immune complexes, causing damage or destruction to tissues or organs. In addition, monocyte chemoattractant proteins (such as MCP-1) produced by monocytes can also participate in the inflammatory response. Most rheumatic diseases, either due to exogenous antigens produced by infection or endogenous antigens produced in the body, can initiate or aggravate this autoimmune response, and a variety of antibodies may appear in the serum.

2. Genetic background: Recent studies have shown that some rheumatic diseases, especially connective tissue diseases, are closely related to genetics and patient susceptibility and disease expression, which has certain significance for early or atypical cases and prognosis of the disease; among them, HLA (human tissue leukocyte antigen) is the most important.

3. Infectious factors: According to research over the years, a variety of infectious factors, antigens or superantigens produced by microorganisms can directly or indirectly stimulate or initiate immune responses.

4. Endocrine factors: Studies have shown that the imbalance of estrogen and progesterone is related to the occurrence of various rheumatic diseases.

5. Environmental and physical factors: ultraviolet rays can induce SLE.

6. Others: Some drugs such as procainamide and some oral contraceptives can induce SLE and ANCA-positive vasculitis

Many mothers who have just given birth are not prepared for the role change. Various inattentions and lack of attention during the confinement period not only bring hidden dangers to the body but also threaten their health. Rheumatism is difficult to cure and brings great pain to women. Severe cases can lead to paralysis. Therefore, we must take more precautions and actively seek treatment after becoming ill.