Treatment for endometrial hyperplasia

I believe everyone knows the importance of the uterus. The uterus is one of the important organs in the female reproductive system. It involves women’s own health, family happiness, economic and social issues, and is closely related to sex and reproduction. Various carelessness in life causes harm to female friends. These pains are likely to cause harm to both men and women. Next, I will introduce to you the treatment method of endometrial hyperplasia.

Treatment:

1. Simple and complex endometrial hyperplasia:

1. Young patients: Most of them suffer from anovulatory functional uterine bleeding. The basal body temperature should be measured. If it is confirmed to be monophasic anovulation, ovulation induction treatment can be used.

2. Reproductive period: Generally, one curettage can control bleeding. If bleeding still occurs after curettage, hysteroscopy and B-ultrasound should be performed to rule out submucosal myoma or other organic lesions. Women with polycystic ovary syndrome who may also experience infertility during the reproductive period and clinically manifest as anovulation should be treated as those with polycystic ovary syndrome.

3. Menopausal transition period: It is often anovulatory functional uterine bleeding. If menstruation is infrequent and the amount of blood is heavy or the bleeding time is long after curettage and hemostasis, progesterone treatment should be given every two months, and follow-up observation should be conducted after 3 cycles.

4. Late menopause: Ask whether to use estrogen replacement therapy alone. After curettage, replacement therapy can be suspended or progestin can be added.

2. Atypical endometrial hyperplasia:

1. Menopausal transition or postmenopause: hysterectomy. Since age is the main risk factor for malignant transformation of endometrial hyperplasia, hysterectomy is appropriate for patients in this age group.

2. Young people or those who want to have children: drug treatment. Atypical hyperplasia is a potentially malignant precancerous lesion, and 20% will develop into cancer if left untreated. However, cancer is less common in young patients, and drug treatment is more effective for young and reproductive patients. Therefore, drug treatment can be chosen to preserve fertility function.

2. Drug treatment:

1. Ovulation-inducing drugs. Ovulation-inducing drugs include chorionic gonadotropin and salpingotropin. It is generally used for patients with mild atypical endometrial hyperplasia.

2. Progestin drugs: Progestin drugs can inhibit endometrial hyperplasia caused by estrogen. Its mechanism of action:

3. Inhibit ovulation and the secretion of pituitary gonadotropin through the hypothalamus and pituitary gland, causing the serum E2 level to drop to the equivalent of the early follicular stage.

4. Reduce the level of estrogen nuclear receptors in the endometrium.

5. Inhibit endometrial DNA synthesis.

6. Increase the activity of estradiol dehydrogenase and isocitrate dehydrogenase, thereby increasing the conversion of estradiol to less active estrogens such as estrone.

Commonly used progestins include progesterone, hydroxyprogesterone caproate, medroxyprogesterone (progesterone acetate) and medroxyprogesterone acetate.

7. Danazol is a derivative of ethinyl-testosterone and is a commonly used drug for the treatment of endometriosis. It has a strong anti-proliferative effect on the endometrium.

8. Cottonpol is an effective drug used in my country to treat endometrial hyperplastic functional uterine bleeding and endometriosis. Its mechanism of action is to inhibit the ovaries, and it also has a specific inhibitory effect on the endometrium. After treatment, the pathological morphology of the endometrium showed a high degree of atrophy and the ultrastructure showed obvious degenerative changes. Peking Union Medical College Hospital has observed preliminary results in the treatment of atypical endometrial hyperplasia with cottonypol. There was 1 case of atypical hyperplasia. After using sedative, the atypical hyperplasia of the endometrium improved, but it still recurred. After 8 months of treatment with cottonpol, the endometrium atrophied and the patient soon became pregnant and gave birth to a boy naturally.

9. GnRH agonists first cause a substantial increase in blood gonadotropin levels, followed by a depletion of the gonadotropin stores in the pituitary gland, which inhibits the pituitary gland and reduces estradiol levels to postmenopausal levels. Therefore, it can also be used for atypical endometrial hyperplasia.

I believe that through the above content everyone has a more comprehensive understanding of the treatment methods for endometrial hyperplasia. I hope these methods can help protect women. We can better improve our bodies to achieve the goal of protecting the uterus, balancing nutrition and strengthening the body! Make your life more harmonious and beautiful while not harming your body.