High blood coagulation in pregnant women

Pregnancy is a special period and it is also a stage that every family pays more attention to. At this time, pregnant women will undergo many prenatal checkups and their bodies will undergo many changes. Due to their physical constitution, living environment, eating habits and other factors, pregnant women will have high blood coagulation. Pregnant women with high blood coagulation should seek medical attention in time to avoid affecting the development and health of the fetus. Normally, the diet should be light.

Blood coagulation process

It can be divided into three basic steps: the formation of the prothrombinase complex (also called the prothrombin activation complex), the activation of prothrombin, and the generation of fibrin.

Coagulation tests

Before the operation, we can understand whether the patient has abnormal coagulation function, effectively prevent unexpected situations such as excessive bleeding during and after the operation, and thus obtain the best surgical effect.

The body's hemostatic function is achieved through the joint action of platelets, coagulation system, fibrinolytic system and vascular endothelial system. In the past, we used bleeding time as a screening test for hemostatic defects, but because its operation is not standardized, its sensitivity is poor, and it cannot reflect the content and activity of coagulation factors, it has now been replaced by coagulation function tests. Coagulation function tests mainly include plasma prothrombin time (PT) and PT activity calculated from PT, international normalized ratio (INR), fibrinogen (FIB), activated partial thromboplastin time (APTT) and plasma thrombin time (TT).

PT mainly reflects the function of the extrinsic coagulation system. Prolonged PT is mainly seen in congenital reduction of coagulation factors II, V, VII, and X, fibrinogen deficiency, acquired coagulation factor deficiency (DIC, primary hyperfibrinolysis, obstructive jaundice, vitamin K deficiency, increased anticoagulants in the blood circulation, etc.); shortened PT is mainly seen in congenital increase of coagulation factor V, early DIC, thrombotic diseases, oral contraceptives, etc.; monitoring of PT can be used as a clinical monitoring of oral anticoagulants.

APTT is the most reliable screening test for intrinsic coagulation factor deficiency. Prolonged APTT is mainly seen in hemophilia, DIC, liver disease, large-scale transfusion of stored blood, etc.; shortened APTT is mainly seen in DIC, prethrombotic state and thrombotic diseases; APTT can be used as a monitoring indicator for heparin treatment.

Prolonged TT is seen in hypofibrinogenemia or afibrinogenemia and dysfibrinogenemia, increased FDP in the blood (DIC), and the presence of heparin and heparin-like substances in the blood (such as during heparin treatment, SLE, liver disease, etc.).

There was an emergency patient who underwent preoperative laboratory tests. The coagulation test results showed prolonged PT and APTT, and the patient was suspected of having DIC. At the suggestion of the laboratory department, the patient underwent a series of DIC tests, and the results were positive, but the patient did not show obvious DIC symptoms. If the patient does not undergo coagulation testing and goes directly to surgery, the consequences will be disastrous. Many problems like these can be discovered from coagulation function tests, which buys more time for timely clinical detection and treatment of diseases. Coagulation series tests are an important laboratory examination of the patient's coagulation function. They can detect abnormal coagulation function in patients before surgery and should be given sufficient attention.