What causes thick uterine membrane?

The uterine membrane is a very private part of women and it also concerns women's physical health, so female friends are very concerned about it. Some women have a uterine membrane that is 5-15mm thicker than normal, which makes them very worried. In fact, this is a common gynecological disease. Most of them are caused by obesity, simple endometrial hyperplasia, endocrine functional tumors, ovarian factors and complex endometrial hyperplasia.

1. Obesity

In obese women, androstenedione secreted by the adrenal glands is converted into estrone by aromatase in adipose tissue; the more adipose tissue there is, the stronger the conversion capacity and the higher the estrone level in the plasma, thus causing a sustained estrogen effect.

2. Simple endometrial hyperplasia

The affected uterus is slightly larger, with a marked thickening of the endometrium, sometimes in a diffuse polyp-like form. The amount of curettage material is large and may be mixed with red, smooth, polyp-like tissue. Microscopically, the lesions are diffuse, involving the functional layer and basal layer of the endometrium, and because of the simultaneous proliferation of the stroma and glands, there is no glandular crowding. The glands vary in size and have smooth contours. The morphology of glandular epithelial cells is similar to that of normal late proliferative phase and has no atypia.

3. Endocrine functional tumors

Endocrine functional tumors are rare tumors, accounting for 7.5%. The gonadotropin function of the pituitary gland is abnormal, and ovarian granulosa cell tumors are also tumors that continuously secrete estrogen.

4. Ovarian factors

During the ovarian cycle, when the follicles in the ovaries mature, the female's endometrium will gradually thicken under the action of estrogen secreted by the ovaries. This provides good conditions for the implantation of the fertilized egg and the growth of the embryo, which is a normal phenomenon.

4. Complex endometrial hyperplasia

The etiology of complex hyperplasia is roughly similar to that of simple hyperplasia, but because the lesions are focal, it may also be related to the distribution of hormone receptors in the tissue. A small number of complex hyperplasias may develop into atypical hyperplasia, thus affecting the prognosis. The diseased endometrium can be thickened or very thin, or it can be polyp-like. Unlike simple hyperplasia, the lesion is a focal proliferation of the glandular components without involving the stroma. The amount of curettage material can be large or small, and is often mixed with normal, atrophic, or other types of hyperplastic endometrium.

Endometrial thickening actually has a great impact on women, and in severe cases it can even affect women's work and study.