Is AST 48 considered high?

Aspartate aminotransferase (AST) is mainly distributed in the heart, followed by tissues such as liver, muscle and kidney. Under normal circumstances, the AST component in blood cells is low, but when relative cell damage occurs, the cytoplasmic permeability increases, and the AST in the cytoplasm is released into the blood. The concentration value of poor blood cells may increase. It is usually used as an auxiliary examination for myocardial infarction and myocarditis in clinical medicine.

The standard value of aspartate transaminase is 0 to 40 units per liter. More than 40 units per liter is called elevated transaminase. 48 exceeds the standard value very rarely. In this case, it is normal for the transaminase standard value to fluctuate slightly. Generally, after a week of rest, when you go for a follow-up visit, your transaminase level will have returned to normal. You can also take some enzyme-lowering and liver-protecting drugs orally.

There are many reasons for increased transaminase. Significant increases are mainly common in subacute viral hepatitis, mild to moderate increases are common in chronic hepatitis, active cirrhosis, liver cancer, hepatitis, cysts, medications and medications that are harmful to the liver, etc. Slight increases can be seen in heart failure during heart disease, myocarditis, myocardial infarction, long-term drinking or drinking a large amount of alcohol at one time, and some bile duct diseases. In addition, normal pregnancy poisoning, acute fatty liver, etc. are also common reasons for increased transaminase. Generally speaking, the level of transaminase elevation is proportional to the level of somatic cell necrosis. Only when the transaminase elevation exceeds the standard value by 2.5 times, liver necrosis is significant and the physiological cause of hepatitis can be considered.

The index values ​​of different groups are different: in normal people, aspartate aminotransferase may be higher than alanine aminotransferase. In hepatitis, when liver damage is dominated by deformation and cell necrosis is not serious, the increase of alanine aminotransferase is significantly higher than that of aspartate aminotransferase. However, in more serious liver diseases such as chronic hepatitis, cirrhosis, and liver cancer, the liver is dominated by necrosis, and the measured elevated level of aspartate aminotransferase at this time significantly exceeds that of alanine aminotransferase.

There are many reasons for high alanine and aspartate aminotransferase levels, such as frequent or long-term drinking, viral hepatitis, active cirrhosis and liver sclerosis, bile duct disease cholecystitis, acute cholelithiasis, toxic hepatitis, various drugs and chemical Chinese medicines, and other infectious diseases. Once the two levels are high, if not treated in time, the virus will gradually cause massive liver death, the symptoms will gradually worsen, and eventually develop into liver cancer.