Causes of cervical papillomavirus infection

There are many causes of cervical papillomavirus infection. If your relatives, friends, or neighbors unfortunately get cervical papilloma, please be sure to read this article carefully. Middle-aged women are particularly prone to cervical papilloma, and the treatment of this disease is particularly difficult. If family members do not take good care of them, infection is easy to occur. Below, let’s talk about cervical papillomavirus infection and its causes.

Human papillomavirus belongs to the genus Papillomavirus of the family Papillomaviridae. It is a spherical, non-enveloped, double-stranded DNA virus with a diameter of 52 to 55 nm. The viral genome is a double-stranded circular DNA, approximately 7.8 to 8.0 kb, divided into early region, late region and regulatory region. The early region encodes proteins related to viral replication, transcriptional regulation and cell transformation (such as E5, E6, E7), and the late region encodes the major capsid protein L1 and the minor capsid protein L2.

This virus cannot be cultured in vitro. There are more than 100 types, and the DNA homology between types is less than 50%. HPV is highly tropistic for skin and mucosal epithelial cells. The nucleic acid in situ hybridization method can detect the early viral genes in the basal cells of the skin; the late genes are only detected in differentiated keratinocytes. Virus replication can induce epithelial hyperplasia, epidermal thickening, accompanied by acanthosis and some degree of epidermal keratinization, and alkalitropic intranuclear inclusions often appear in the granular layer. Epithelial proliferation forms papillomas, also known as warts.

Pathogenicity and immunity: HPV is mainly transmitted through contact with infected areas or contaminated objects. Genital infection is mainly transmitted through sexual intercourse. The life cycle of the new papillomavirus is closely related to the differentiation of epidermal cells. Newborns may be infected in the birth canal. Viral infections are usually localized and do not spread through the bloodstream. Different types of HPV can cause papilloma in different parts of the body. Skin warts are generally benign, HPV DNA is free, and some warts can disappear on their own. High-risk human papillomavirus is closely related to genital precancerous lesions and malignant tumors, and HPV DNA is often integrated into the chromosomes of host cells.

The above introduces the causes of cervical papillomavirus infection in detail. I hope that these can reduce the suffering of patients with cervical papilloma. If everyone understands the causes of viral infection, they will pay attention to these problems and avoid viral infection. Family members of patients with cervical papilloma at home should also read this article in detail.