What are the dangers of excessive estrogen?

Estrogen has a huge effect on the human body. Once the level is too high, it will cause great harm to the body. Patients will experience thickening of the endometrium, which will not fall off and amenorrhea. It will also lead to endocrine disorders and gynecological diseases such as breast hyperplasia. If it continues for a long time, it will cause abnormal proliferation of the endometrium and even hair cancer.

1. The harm of excessive estrogen

1. Obese people have too much fat, which will increase the storage of estrogen or convert more androgens into estrogen, thereby causing the estrogen level in the body to increase and the duration of action to prolong.

2. Estrogen is involved in the formation of the menstrual cycle. During the follicular phase, estrogen levels rise, causing the endometrium to thicken. If estrogen levels are too high before menstruation, it will affect the normal shedding of the endometrium and menstruation will not occur.

3. Estrogen can stimulate breast hyperplasia, and high levels can easily induce breast cancer. Most breast diseases are caused by excessively high estrogen levels and endocrine disorders.

4. Uterine fibroids are an estrogen-dependent tumor and are related to sex hormone levels. Therefore, uterine fibroids are more likely to occur in women of childbearing age with strong ovarian function.

5. Estrogen and progesterone act together on the endometrium, causing the endometrial epithelial cells to proliferate and shed periodically, leading to menstruation. If the amount of estrogen increases relatively, the endometrium will proliferate abnormally, which can easily induce cancer.

6. Estrogen can promote the development of follicles. If the estrogen content is too high, it will affect the normal development of follicles and may cause ovulation disorders or infertility.

How does estrogen cause breast cancer?

At present, there is no large-sample evidence-based data at home and abroad to confirm that hormone replacement therapy has a clear correlation with the occurrence of uterine cancer and breast cancer. However, a study in the United States on "observing the use of hormone replacement therapy in postmenopausal women" was stopped halfway. One of the reasons was that the risk of breast cancer exceeded the expected number. At least one thing is certain, hormone replacement therapy stimulates the breasts and uterus to a certain extent, causing the glands that have begun to degenerate to develop again, and the incidence of breast hyperplasia or endometrial thickening is indeed increased. The results of a survey conducted by the American Women's Health Promotion Association among nearly 170,000 American female volunteers showed that the incidence of breast cancer increased significantly among women who took estrogen and progesterone at the same time. The entry of exogenous hormones can easily lead to an imbalance in hormone secretion in the body, causing disorders in the levels of multiple hormones such as estrogen. If the disorder lasts too long, the breast duct epithelial cells will develop from simple hyperplasia to abnormal hyperplasia under its stimulation, which may lead to cancer.